Coming from Toronto I have to admit, the "club" scene here is generally weak. (Club as in multi plex dance clubs..)
I am so far removed from that scene anymore, I couldn't tell you what is happening where at this stage. Well, I suppose I could if it was Whistler.
You could always crawl all the clubs, pubs and bars. Start at Robson and Granville, head to Denman then to Davie and loop back. You will find something in that range to suit your needs. I know there is at least one or two clubs down seymour as well. Near Georgia.
Sorry I don't know the area as well anymore, since leaving Vancouver proper.